Table 2.
Contributions of Proxy Genetic and Non-Genetic Risksa to Level of and Change in Mental Health
| Level of Mental Health | Model 1 (%) | Model 2 (%) | Model 3 (%) | Model 4 (%) | Model 5 (%) | % Model 5 (%) |
|---|---|---|---|---|---|---|
| −Time | 1.8 | 1.8 | 1.8 | 1.8 | 1.8 | |
| −PRS | 0.6 | 0.5 | 0.4 | 2.5 | ||
| −Age/sex | 1.7 | 1.2 | 1.2 | 1.1 | 0.9 | 5.3 |
| −Family history | 6.1 | 6.0 | 4.1 | 24.3 | ||
| −Environmental risks | 4.5 | 3.7 | 22.2 | |||
| −Pain | 2.9 | 2.6 | 15.6 | |||
| −Social circumstances | 5.5 | 5.1 | 30.2 | |||
| Totalb | 2.3 | 7.3 | 7.7 | 14.0 | 16.7 | |
| Change in mental health | ||||||
| −Time | 1.8 | 1.8 | 1.8 | 1.8 | 1.8 | |
| −PRS | 0.3* | 0.3* | 0.2* | 2.1 | ||
| −Age/sex | 1.0 | 0.8 | 0.8 | 0.7 | 0.6 | 5.5 |
| −Family history | 3.7 | 3.7 | 2.7 | 23.4 | ||
| −Environmental risks | 3.2 | 2.8 | 23.7 | |||
| −Pain | 2.1 | 2.0 | 16.8 | |||
| −Social circumstances | 3.5 | 3.3 | 28.6 | |||
| Totalb | 1.3 | 4.5 | 4.7 | 9.6 | 11.7 |
Note: Model 1: PRS-SZ only; model 2: family history only; model 3: PRS-SZ and family history; model 4: environmental risks (childhood trauma, regular cannabis use, and urban environment), pain, and social circumstances (living alone, jobless, income, educational level, recent life events, no partner, perceived status gap, disability payment, and debts); model 5: all factors of models 3 and 4 combined; %model 5: as a percentage of total variance explained. All associations with regressor groups displayed in the table are statistically significant except marked with *.
aContributions of genetic principal components not displayed.
bExcludes contribution of factor “time.”