Table 5.
Relationships Between BDNF, Oxidative Stress Markers, and Cognitive Function in DNFE Patientsa
Immediate Memory | Attention | Language | Visuospatial/Constructional | Delayed Memory | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
r | P | P b | r | P | P b | r | P | P b | r | P | P b | r | P | P b | |
DNFE patients | |||||||||||||||
BDNF | −.09 | .20 | n.s. | −.08 | .25 | n.s. | −.04 | .60 | n.s. | .01 | .94 | n.s. | −.07 | .34 | n.s. |
Total SOD | −.05 | .42 | n.s. | −.12 | .07 | n.s. | −.05 | .49 | n.s. | −.05 | .42 | n.s. | −.07 | .34 | n.s. |
CuZn-SOD | .11 | .09 | n.s. | .16 | .02 | n.s. | .12 | .06 | n.s. | .15 | .03 | n.s. | .01 | .92 | n.s |
Mn-SOD | −.17 | .01 | n.s. | −.25 | <.01 | s. | −.06 | .19 | n.s. | −.17 | .02 | n.s. | .05 | .50 | n.s. |
MDA | −.06 | .51 | n.s. | −.18 | .01 | n.s. | .05 | .59 | n.s. | .05 | .59 | n.s. | .03 | .73 | n.s. |
Healthy controls | |||||||||||||||
BDNF | −.01 | .91 | n.s. | −.03 | .53 | n.s. | −.03 | .95 | n.s. | −.09 | .98 | n.s. | −.09 | .90 | n.s. |
Total SOD | .03 | .73 | n.s. | .10 | .09 | n.s. | −.01 | .80 | n.s. | .07 | .14 | n.s. | .10 | .10 | n.s. |
CuZn-SOD | −.07 | .30 | n.s. | −.18 | <.01 | n.s. | −.14 | <.01 | n.s. | −.15 | <.01 | n.s. | −.04 | .58 | n.s. |
Mn-SOD | .08 | .23 | n.s. | −.19 | <.01 | n.s | .06 | .19 | n.s. | .19 | <.01 | n.s. | .15 | <.01 | n.s. |
MDA | −.03 | .96 | n.s. | −.02 | .79 | n.s. | −.29 | .59 | n.s. | .11 | .04 | n.s. | .11 | .04 | n.s. |
Note: n.s., nonsignificant; s., significant.
aPearson product moment.
bAfter controlling for age, sex, smoking and BMI, no significant association was found between cognitive function and BDNF, MDA, SOD enzyme activities in the healthy controls (all P > .05).