FIGURE 1.
CBD reduces seizure severity in different rat models of chemically induced acute seizure. Intraperitoneal CBD (100 mg·kg−1) caused a significant reduction in seizure severity induced by pentylenetetrazole (80 mg·kg−1 i.p., n = 15; Jones et al., 2010), penicillin 525 IU intracerebroventricular infusion (n = 17–18; Jones et al., 2012), or pilocarpine (380 mg·kg−1 i.p., n = 15; Jones et al., 2010). Intravenous CBD (10 mg·kg−1) caused a significant reduction in seizure severity induced by pilocarpine (380 mg·kg−1 i.v., n = 12–15; Patra et al., 2019). *P < 0.05, nonparametric binomial test