TABLE 3.

Tg26 mice show no overt deficits in sensory and motor functions

Genotype	Sex	Body weight (g)	Body temp. (°C)	Spontaneous activity	Righting reflex	Bite irritability	Pupil reflex	Visual reflex	Grip strength	Wire maneuver
WT	Male	37.4 ± 1.35	36.8 ± 0.16	2.2 ± 0.22	3.0	1.0 ± 0.35	1.00 ± 0.00	2.4 ± 0.27	2.8 ± 0.22	3.8 ± 0.22
Tg26	Male	29.8 ± 1.24*	36.9 ± 0.15	2.8 ± 0.22	3.0	1.2 ± 0.42	1.00 ± 0.00	2.8 ± 0.22	2.2 ± 0.22	3.4 ± 0.45
WT	Female	26.0 ± 1.25	36.9 ± 0.28	2.8 ± 0.29	3.0	2.8 ± 0.29	0.75 ± 0.17	2.5 ± 0.33	2.0 ± 0.00	3.0 ± 0.00
Tg26	Female	22.3 ± 0.73*	37.0 ± 0.21	3.0 ± 0.00	3.0	2.5 ± 0.58	0.50 ± 0.00	2.5 ± 0.33	1.8 ± 0.29	3.5 ± 0.58

Note: Male and female Tg26 and littermate WT mice were assessed for differences in physiological, sensory, motor and reflexive responses by a modified SmithKline Beecham, Harwell, Imperial College, Royal London Hospital Phenotype Assessment screen (see section 2.4 for scoring criteria used). Both male and female Tg26 mice had lower body mass compared to their respective WT controls. n = 5 per each group; unpaired Student's t‐test. Data are presented as the mean ± SEM.

^* P < 0.05.