FIGURE 4.
Development of dyskinesia induced by chronic l‐DOPA treatment (21 days; sixth, seventh and eighth week) at high (12 mg·kg−1, white circles; n = 6) and low (6 mg·kg−1, black circles; n = 11) doses. Total AIM score (a) was estimated as the addition of limb (b), orolingual (c) and axial (d) components. Rotational movement was recorded as locomotive component (e). Data are means ± SEM. *P < 0.05 (unpaired Student's t test for each time point). Student's t‐test (AUC) and two‐way ANOVA for repeated measures and Holm–Sidak post hoc test. AIMs, abnormal involuntary movements