FIGURE 6.
Effect of acute l‐DOPA treatment on RhoA and ROCK mRNA levels. A single injection of a high dose of l‐DOPA (LD; 12 mg·kg−1) induced dyskinesia and a significant increase in RhoA (a, b) and ROCK (c, d) mRNA levels in the substantia nigra (a, c) and striatum (b, d). In (a)–(d), the results were normalized to the values of 6‐OHDA‐lesioned rats treated with saline. Time course of total AIMs (e) and the limb component (f) in rats subjected to a single l‐DOPA injection and killed 1 h (n = 5) and 4 h (n = 5) after injection. Data are means ± SEM. *P < 0.05 (Student's t test)