FIGURE 7.
Effect of fasudil (10 or 40 mg·kg−1; F‐10, F‐40) compared to non‐lesioned controls and untreated 6‐OHDA‐lesioned rats on markers related to angiogenesis and neuroinflammation in the substantia nigra. Protein levels of the angiogenesis‐related factor VEGF (a, b) and the pro‐inflammatory markers IL‐1β (c) and TNF‐α (d) were increased in rats subjected to l‐DOPA treatment and significantly decreased in rats treated with l‐DOPA (6 mg·kg−1) and fasudil, as determined by WB (a–c) and elisa analysis (d). The results were normalized to the values of non‐lesioned controls. Data are means ± SEM. *P < 0.05, significant difference relative to controls; # P < 0.05, significant difference relative to l‐DOPA‐treated animals (one‐way ANOVA and Holm–Sidak post hoc test)