FIGURE 7.
Schematic summarizing the effects of mavacamten on myocardial contractility at the myofilament level. Building from Figure 1, this schematic represents additional steps of the cross‐bridge cycle associated with Pi and ADP release from myosin, ATP association and cross‐bridge detachment, followed by ATP hydrolysis to reprime myosin for another force‐generating event or relaxation. Blue text denotes known influences of mavacamten, which are further discussed in the text