TABLE 1.
Body weight, liver lipids, and serum parameters of timed WD-fed male B6/129 mice
| RC | WD | ||
| 2 Weeks | 4 Weeks | ||
| Body weight (g) | 36.2 ± 1.19 | 39.6 ± 0.770 | 42.1 ± 0.524a |
| Liver TG (mg/g) | 18.9 ± 2.25 | 270 ± 41.8b | 452 ± 46.7b |
| Liver TC (mg/g) | 10.3 ± 3.05 | 8.90 ± 0.859 | 24.1 ± 1.64a |
| Serum TG (mg/dl) | 101 ± 15.0 | 73.6 ± 5.98c | 137 ± 15.4 |
| Serum TC (mg/dl) | 151 ± 14.9 | 231 ± 20.0a | 227 ± 6.45b |
| ALT (U/ml) | 32.6 ± 2.77 | 74.0 ± 12.3a | 102 ± 11.3b |
| AST (U/ml) | 89.0 ± 27.6 | 84.0 ± 3.29a | 81.0 ± 6.24 |
| Serum glucose (mg/dl) | 284 ± 37.4 | 369 ± 12.9 | 358 ± 10.7 |
| Serum insulin (ng/ml) | 1.15 ± 0.305 | 4.65 ± 0.752b | 3.4 ± 1.2 |
| Serum glucagon (pg/ml) | 52.1 ± 4.19 | 41.2 ± 3.78 | 66.7 ± 19.4 |
| HOMA-IR | 0.875 ± 0.314 | 4.14 ± 0.595b | 3.45 ± 1.26 |
Values are expressed as mean ± SE. B6/129 mice fed WD for 2 weeks (n = 5) and 4 weeks (n = 4). All mice were 11 weeks old when euthanized. Controls were the age-matched B6/129 mice fed a RC diet (n = 5).
a
P < 0.05 versus control group (RC), by Welch’s t-test.
b
P < 0.01 versus control group (RC), by Welch’s t-test.
c
P < 0.001 versus control group (RC), by Welch’s t-test.