TABLE 2.
Liver bile acid compositions of the timed WD-fed B6/129 mice
| RC (Control) (n = 5) | WD | |||
| Week 2 (n = 5) | Week 4 (n = 4) | Week 6 (n = 3) | ||
| Total bile acid | 210 ± 67.0 | 195 ± 36.4 | 278 ± 191 | 131 ± 12.5 |
| TCA | 92.1 ± 35.2 | 55.1 ± 14.3 | 112 ± 79.4 | 49.7 ± 6.26 |
| CA | 2.38 ± 0.64 | 1.67 ± 0.26 | 1.88 ± 0.99 | 1.66 ± 0.417 |
| TCA-7S | 2.02 ± 0.401 | 2.53 ± 0.181 | 3.08 ± 0.911 | 2.07 ± 0.209 |
| TCDCA | 8.12 ± 2.92 | 7.29 ± 1.29 | 8.62 ± 4.35 | 6.70 ± 0.683 |
| CDCA | 1.45 ± 0.29 | 0.67 ± 0.04 | 0.58 ± 0.171 | 0.48 ± 0.162 |
| TUDCA | 1.93 ± 0.59 | 2.08 ± 0.44 | 3.41 ± 2.14 | 1.55 ± 0.176 |
| UDCA | 0.60 ± 0.15 | 1.48 ± 0.14a | 1.19 ± 0.61 | 0.79 ± 0.233 |
| TDCA | 3.90 ± 1.09 | 1.39 ± 0.23 | 2.48 ± 1.13 | 3.60 ± 0.324 |
| THDCA | 1.59 ± 0.43 | nd | nd | nd |
| T-αMCA | 4.92 ± 1.70 | 4.14 ± 1.40 | 5.11 ± 2.93 | 4.07 ± 1.21 |
| αMCA | 3.32 ± 0.85 | 5.13 ± 0.75 | 3.10 ± 1.34 | 2.24 ± 0.190 |
| T-βMCA | 54.5 ± 18.1 | 43.6 ± 10.8 | 83.9 ± 66.7 | 22.4 ± 5.85 |
| βMCA | 15.9 ± 2.78 | 62.4 ± 8.04a | 46.5 ± 28.0 | 28.7 ± 0.687b |
| T-ωMCA | 11.4 ± 3.28 | 2.20 ± 0.661b | 2.27 ± 1.50b | 1.97 ± 0.531 |
| ωMCA | 6.19 ± 0.83 | 3.88 ± 0.62 | 2.87 ± 1.34 | 3.71 ± 0.939 |
| T-Δ22-βMCA | 1.16 ± 0.37 | 1.53 ± 0.34 | 1.95 ± 0.92 | 1.49 ± 0.661 |
| MDCA | nd | nd | 0.46 ± 0.13 | nd |
| TCA-6α-ol | 0.62 ± 0.16 | nd | nd | nd |
| T-isoLCA-Δ5-3S | nd | 0.38 ± 0.08 | nd | nd |
Values are expressed as mean ± SE in nanomoles per gram of tissue. Total bile acid represents sum of 124 bile acids (supplemental Table S1) measured. Only detected bile acids are presented above. nd, not detected; THDCA, taurohyodeoxycholic acid; T-Δ22-βMCA, tauro 3α,6β,7β-trihydroxychol-5,22-diene-24-oic acid; MDCA, murideoxycholic acid; TCA-6α-ol, tauro 6α-hydroxycholic acid; T-isoLCA-Δ5-3S, tauro 3β-sulfoxy-5-cholen-24-oic acid.
a
P < 0.01 versus control group (RC), by Welch’s t-test.
b
P < 0.05 versus control group (RC), by Welch’s t-test.