TABLE 2.
Summary of the kinetic parameter of the ATPase activity of ABCB4 in the presence of different building blocks ranging from choline to PC lipid
| Name | MM (Da) | k1 (%) | k2 (μM) | v1 (%) | Mod. |
| LPC | 495 | — | 103.9 ± 7.7 | — | Inhibition |
| FC-16 | 407 | — | 41.9 ± 11.3 | — | Inhibition |
| 16:0-18:1 PC | 760 | 51.3 ± 25.2 | — | 260.8 ± 25.5 | Stimulation |
LPC, Lyso-16:0 PC; FC-16, Fos-choline 16; 16:0-18:1 PC, 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine. The PC proportion of the canalicular membrane was calculated according to (29). LPC, Lyso-16:0 PC; FC-16, Fos-choline 16; 16:0-18:1 PC, 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine; MW, molecular mass; k1, concentration at half-maximal stimulation; k2, concentration at half-maximal inhibition; v1, maximal stimulation; Mod., nature of modulation on ABCB4.