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. 2020 Oct 2;61(12):1764–1775. doi: 10.1194/jlr.RA120001121

Fig. 5.

Fig. 5.

miR-23a-3p regulates TNFAIP3 expression in HAECs. A: Prediction of the binding sequence of the human TNFAIP3 gene with miR-23a-3p and design of the mutant TNFAIP3 binding site. B: Luciferase reporter assay of 293T cells cotreated with miR-23a-3p and empty vector or vectors containing WT TNFAIP3 3′UTR or TNFAIP3 3′UTR mutant. C: Effect of miR-23a-3p on the transcription level of TNFAIP3 in HAECs. D: Gene expression of TNFAIP3. E: Protein expression of TNFAIP3. Error bars represent standard deviations. *P < 0.05, **P < 0.01, ***P < 0.001; multiple comparisons were performed by one-way ANOVA followed by post hoc Dunnett’s test (C) and Tukey’s test (D, E). Group pairs were compared by the Student’s t-test (B).