Table 2. Incidence rate and hazard ratio of osteoporosis or bone fracture in women with hysterectomy and oophorectomy compared with the comparison group.
| Crude | Adjusted* | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Event | PY | IR | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Osteoporosis or bone fracture | |||||||||
| Hysterectomy | Oophorectomy | ||||||||
| No | No | 32896 | 1776 | 243262 | 7.30 | 1.00 (reference) | 1.00 (reference) | ||
| No | unilateral | 477 | 36 | 3503 | 10.28 | 1.40 (1.01,1.95) | 0.04 | 1.63 (1.17,2.27) | 0.004 |
| No | bilateral | 569 | 55 | 5128 | 10.73 | 1.44 (1.10,1.89) | 0.01 | 2.04 (1.55,2.67) | <0.001 |
| Yes | No | 8224 | 954 | 57885 | 16.48 | 2.27 (2.10,2.45) | <0.001 | 2.26 (2.09,2.44) | <0.001 |
| Yes | unilateral | 531 | 22 | 2608 | 8.44 | 1.21 (0.80,1.85) | 0.37 | 1.30 (0.86,1.99) | 0.22 |
| Yes | bilateral | 434 | 73 | 3727 | 19.59 | 2.66 (2.10,3.36) | <0.001 | 2.95 (2.33,3.73) | <0.001 |
| Osteoporosis | |||||||||
| Hysterectomy | Oophorectomy | ||||||||
| No | No | 32242 | 1122 | 243262 | 4.61 | 1.00 (reference) | 1.00 (reference) | ||
| No | unilateral | 453 | 12 | 3503 | 3.43 | 0.77 (0.43,1.35) | 0.36 | 0.94 (0.53,1.65) | 0.82 |
| No | bilateral | 534 | 20 | 5128 | 3.90 | 0.85 (0.55,1.32) | 0.47 | 1.36 (0.87,2.12) | 0.17 |
| Yes | No | 7655 | 385 | 57885 | 6.65 | 1.50 (1.34,1.69) | <0.001 | 1.52 (1.36,1.71) | <0.001 |
| Yes | unilateral | 517 | 8 | 2608 | 3.07 | 0.70 (0.35,1.40) | 0.31 | 0.76 (0.38,1.52) | 0.44 |
| Yes | bilateral | 389 | 28 | 3727 | 7.51 | 1.72 (1.18,2.50) | 0.005 | 1.96 (1.34,2.85) | <0.001 |
| Hip fracture | |||||||||
| Hysterectomy | Oophorectomy | ||||||||
| No | No | 31198 | 78 | 243262 | 0.32 | 1.00 (reference) | 1.00 (reference) | ||
| No | unilateral | 442 | 1 | 3503 | 0.29 | 0.90 (0.13,6.47) | 0.92 | 1.08 (0.15,7.80) | 0.94 |
| No | bilateral | 517 | 3 | 5128 | 0.59 | 1.86 (0.59,5.91) | 0.29 | 3.27 (1.02,10.51) | 0.05 |
| Yes | No | 7288 | 18 | 57885 | 0.31 | 1.02 (0.61,1.70) | 0.95 | 1.07 (0.64,1.79) | 0.80 |
| Yes | unilateral | 509 | 2 | 2608 | 0.77 | -- | -- | ||
| Yes | bilateral | 363 | 2 | 3727 | 0.54 | 1.88 (0.46,7.64) | 0.38 | 2.75 (0.67,11.28) | 0.16 |
| Vertebral fracture | |||||||||
| Hysterectomy | Oophorectomy | ||||||||
| No | No | 31225 | 105 | 243262 | 0.43 | 1.00 (reference) | 1.00 (reference) | ||
| No | unilateral | 447 | 6 | 3503 | 1.71 | 4.03 (1.77,9.17) | <0.001 | 4.64 (2.03,10.6) | <0.001 |
| No | bilateral | 517 | 3 | 5128 | 0.59 | 1.33 (0.42,4.20) | 0.62 | 1.79 (0.56,5.68) | 0.32 |
| Yes | No | 7390 | 120 | 57885 | 2.07 | 5.02 (3.86,6.52) | <0.001 | 4.92 (3.78,6.40) | <0.001 |
| Yes | unilateral | 510 | 1 | 2608 | 0.38 | 0.98 (0.14,7.00) | 0.98 | 1.05 (0.15,7.56) | 0.96 |
| Yes | bilateral | 367 | 6 | 3727 | 1.61 | 3.87 (1.70,8.80) | 0.001 | 4.50 (1.97,10.29) | <0.001 |
| Other bone fracture | |||||||||
| Hysterectomy | Oophorectomy | ||||||||
| No | No | 31599 | 479 | 243262 | 1.97 | 1.00 (reference) | 1.00 (reference) | ||
| No | unilateral | 459 | 18 | 3503 | 5.14 | 2.59 (1.62,4.14) | <0.001 | 2.94 (1.83,4.71) | <0.001 |
| No | bilateral | 544 | 30 | 5128 | 5.85 | 2.92 (2.02,4.22) | <0.001 | 3.59 (2.47,5.21) | <0.001 |
| Yes | No | 7723 | 453 | 57885 | 7.83 | 4.04 (3.56,4.60) | <0.001 | 3.97 (3.49,4.51) | <0.001 |
| Yes | unilateral | 522 | 13 | 2608 | 4.98 | 2.60 (1.50,4.52) | <0.001 | 2.66 (1.53,4.61) | <0.001 |
| Yes | bilateral | 398 | 37 | 3727 | 9.93 | 5.17 (3.70,7.22) | <0.001 | 5.44 (3.89,7.61) | <0.001 |
PY: Person-years; IR: Incidence rate per 1,000 person-years; HR: Hazard ratio; CI: Confidence interval.
*: Model was adjusted for age, urbanization, insurance premium, occupation, estrogen treatment, and Charlson comorbidity index.