Table 3. Adjusted hazard ratio and 95% confidence interval of osteoporosis or fracture between women with hysterectomy or oophorectomy stratified by age.
| Comparison group without oophorectomy | Comparison group with oophorectomy | Hysterectomy only | Hysterectomy with oophorectomy | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | HR* (95% CI) | p-value | HR* (95% CI) | p-value | HR* (95% CI) | p-value | |
| Osteoporosis | |||||||
| All | 1.00 (reference) | 0.84 (0.59,1.2) | 0.35 | 1.44 (1.28,1.61) | <0.001 | 1.30 (0.94,1.82) | 0.12 |
| Age | |||||||
| 30–39 | 1.00 (reference) | 0.77 (0.24,2.48) | 0.66 | 2.31 (1.39,3.84) | 0.001 | 1.00 (0.14,7.28) | 1.00 |
| 40–49 | 1.00 (reference) | 1.05 (0.61,1.82) | 0.86 | 1.67 (1.42,1.97) | <0.001 | 2.03 (1.38,2.99) | <0.001 |
| 50–59 | 1.00 (reference) | 2.46 (1.43,4.22) | 0.001 | 1.18 (0.90,1.56) | 0.23 | 0.84 (0.37,1.88) | 0.67 |
| ≧60 | 1.00 (reference) | 0.41 (0.1,1.65) | 0.21 | 1.37 (1.08,1.74) | 0.01 | 0.55 (0.14,2.23) | 0.41 |
| Hip fracture | |||||||
| All | 1.00 (reference) | 1.52 (0.56,4.17) | 0.41 | 0.92 (0.55,1.54) | 0.74 | 1.00 (0.25,4.08) | 1.00 |
| Age | |||||||
| 30–39 | 1.00 (reference) | -- | 7.87 (1.20,51.62) | 0.03 | -- | ||
| 40–49 | 1.00 (reference) | -- | 1.19 (0.48,2.95) | 0.70 | 1.90 (0.26,14.14) | 0.53 | |
| 50–59 | 1.00 (reference) | 4.50 (0.56,36.26) | 0.16 | 0.91 (0.20,4.15) | 0.90 | 3.09 (0.38,24.87) | 0.29 |
| ≧60 | 1.00 (reference) | 3.84 (1.18,12.47) | 0.02 | 0.76 (0.34,1.70) | 0.51 | -- | |
| Vertebral fracture | |||||||
| All | 1.00 (reference) | 2.47 (1.25,4.88) | 0.01 | 4.67 (3.59,6.08) | <0.001 | 2.75 (1.28,5.91) | 0.01 |
| Age | |||||||
| 30–39 | 1.00 (reference) | 1.25 (0.15,10.57) | 0.84 | 8.60 (3.4,21.72) | <0.001 | 5.99 (0.73,48.92) | 0.09 |
| 40–49 | 1.00 (reference) | 3.00 (1.21,7.43) | 0.02 | 3.19 (2.22,4.56) | <0.001 | 2.98 (1.20,7.41) | 0.02 |
| 50–59 | 1.00 (reference) | 5.70 (0.71,45.90) | 0.10 | 10.03 (4.38,22.97) | <0.001 | 3.59 (0.44,29.31) | 0.23 |
| ≧60 | 1.00 (reference) | 6.15 (1.43,26.45) | 0.01 | 7.73 (4.45,13.43) | <0.001 | -- | |
| Other bone fracture | |||||||
| All | 1.00 (reference) | 2.83 (2.10,3.80) | <0.001 | 3.91 (3.44,4.45) | <0.001 | 4.16 (3.10,5.57) | <0.001 |
| Age | |||||||
| 30–39 | 1.00 (reference) | 3.27 (1.66,6.45) | <0.001 | 6.31 (4.09,9.74) | <0.001 | 9.50 (4.38,20.63) | <0.001 |
| 40–49 | 1.00 (reference) | 2.76 (1.79,4.25) | <0.001 | 3.33 (2.83,3.92) | <0.001 | 4.18 (2.95,5.92) | <0.001 |
| 50–59 | 1.00 (reference) | 4.78 (2.30,9.95) | <0.001 | 4.51 (3.26,6.26) | <0.001 | 2.85 (1.24,6.59) | 0.01 |
| ≧60 | 1.00 (reference) | 8.49 (3.82,18.88) | <0.001 | 5.93 (4.04,8.72) | <0.001 | 1.75 (0.24,12.79) | 0.58 |
PY: Person-years; IR: Incidence rate per 1,000 person-years; HR: Hazard ratio; CI: Confidence interval.
*: Model was adjusted for age, urbanization, insurance premium, occupation, estrogen treatment, and Charlson comorbidity index.