Table 3. Fungal genera exhibiting significant differential abundance (BH corrected P ≤0.05) between the gut mycobiomes of Healthy controls (HC, n = 30) and Diabetes Mellitus (T2DM, n = 21) individuals.
| S. No. | Genus | Median Abundance (%)* | Wilcoxon test—P value (BH corrected P value ≤ 0.05)† | Pathogenicity | |
|---|---|---|---|---|---|
| HC | T2DM | ||||
| Genera decreased in T2DM | |||||
| 1 | Issatchenkia | 2.387 | 0.093 | 0 | Plant/Human pathogen |
| 2 | Macrophomina | 0.616 | 0 | 0 | Plant pathogen |
| 3 | Marasmius | 0.451 | 0.215 | 0 | Commensal |
| 4 | Gymnopilus | 0.308 | 0.123 | 0.043 | Commensal |
| 5 | Saccharomyces | 0.261 | 0.127 | 0 | Non pathogen |
| 6 | Trichoderma | 0.134 | 0.05 | 0.043 | Plant pathogen |
| 7 | Cochliobolus | 0.114 | 0 | 0 | Plant pathogen |
| 8 | Psathyrella | 0.102 | 0.031 | 0.043 | Commensal |
| 9 | Clavispora | 0.027 | 0.001 | 0 | Not known |
| 10 | Didymella | 0.011 | 0.002 | 0 | Plant pathogen |
| 11 | Ganoderma | 0.007 | 0 | 0.043 | Plant pathogen |
| 12 | Rhizopus | 0.006 | 0 | 0 | Plant/Human pathogen |
| 13 | Mycosphaerella | 0.005 | 0.003 | 0.043 | Plant pathogen |
| 14 | Wickerhamomyces | 0.005 | 0 | 0 | Antimicrobial |
| 15 | Gliocladiopsis | 0.004 | 0 | 0 | Plant pathogen |
| 16 | Cuphophyllus | 0.002 | 0 | 0 | Commensal |
| 17 | Cylindrocladiella | 0.002 | 0 | 0 | Plant pathogen |
| 18 | Backusella | 0.001 | 0 | 0 | Not known |
| 19 | Corynespora | 0.001 | 0 | 0 | Plant pathogen |
| 20 | Vishniacozyma | 0.001 | 0 | 0.043 | Antimicrobial |
| 21 | Volutella | 0.001 | 0 | 0.043 | Plant pathogen |
| Genera increased in T2DM | |||||
| 1 | Candida | 0.878 | 8.119 | 0 | Human pathogen |
| 2 | Cladosporium | 0.023 | 0.658 | 0 | Plant pathogen |
| 3 | Kodamaea | 0.001 | 0.014 | 0.043 | Human pathogen |
| 4 | Meyerozyma | 0.001 | 0.067 | 0 | Human pathogen |
| 5 | Mortierella | 0 | 0.187 | 0 | Soil fungi |
*Differentially abundant genera having a median abundance ≥ 0.001% in at least one group of samples are listed.
†P value of 0 indicates ≤ 0.0001.