Table 2. Meta-regression analysis for different parameters.

Parameter		Sensitivity (95% CI)	Specificity (95% CI)
Type of study	Prospective (2 studies)	32% (20–43%)	97% (94–99%)
	Retrospective (2 studies)	82% (73–91%)	100% (100–100%)
	Meta-regression P-value	<0.01	<0.01
Homogenization	Mechanical (2 studies)	82% (73–91%)	100% (100–100%)
	No (2 studies)	32% (20–43%)	97% (94–99%)
	Meta-regression P-vaule	<0.01	<0.01
Sample pre-treatment	With bead-beating (3 studies)	66% (38–93%)	98% (94–100%)
	Without bead-beating (1 study)	43% (11–98%)	97% (91–100%)
	Meta-regression P-vaule	0.39	0.03
Patient selection	Consecutive (1 study)	43% (11–98%)	97% (91–100%)
	Convenience (3 studies)	66% (38–93%)	98% (94–100%)
	Meta-regression P-vaule	0.44	0.21

CI: confidence interval