Table 3. IC₅₀ Values (μM, Mean ± SEM) of the Diastereomeric and/or Racemic Mixtures^a.

	calculated IC50 values (μM ± SEM)
compound	MCF-7	HeLa	C33A	A2780	NIH/3T3
juncuenin B	–	2.9 ± 0.5b	–	7.3 ± 1.3b	>30
1a–1d	–	–	6.7 ± 0.5	7.7 ± 1.0	17.7 ± 0.7
4a+4b	6.5 ± 1.1	1.9 ± 0.4	7.0 ± 1.8	9.1 ± 0.5	14.9 ± 3.7
7a+7b	6.2 ± 0.2	5.4 ± 0.1	6.1 ± 0.4	5.9 ± 1.1	>30
cisplatin	5.8	–	1.8	1.3b	2.7

^aCompounds 2a, 2b, 3, 5, 6b, 8, 9, and 10 were found to be inactive or moderately active (Table S1, Supporting Information). Determinations were performed using an MTT assay by treating the cells with compounds (0.1–30 μM) for 72 h. Data are based on two independent experiments.

^bIC₅₀ value from literature.¹⁰