Table 4. IC50 Values of the Enantiopure Compounds 1a–1d, 4a, 4b, 7a, and 7ba.
| Calculated
IC50 values (μM ± SEM) |
||||||
|---|---|---|---|---|---|---|
| compound | MCF-7 | T47D | HeLa | C33A | A2780 | NIH/3T3 |
| (1R,8aS)-1b | – | – | – | – | 9.0 ± 1.0 | >30 |
| (1S,8aR)-1c | – | – | – | 5.3 ± 0.9 | 7.7 ± 0.6 | 21.6 ± 0.4 |
| (8aR)-4a | 6.2 ± 1.6 | – | 0.9 ± 0.4 | 5.3 ± 0.6 | 8.7 ± 0.8 | 25.8 ± 4.6 |
| (8aR)-7a | – | 8.8 ± 1.1 | 3.7 ± 0.9 | 4.9 ± 0.3 | 2.8 ± 0.3 | >30 |
| cisplatin | 5.8 | 9.8b | –b | 1.8 | 1.3b | 2.7 |
a
Determinations were performed using an MTT assay by treating the cells with compounds (0.1–30 μM) for 72 h. Data are based on two independent experiments.
b
IC50 value from literature.10