Table 2.
Demographic data and clinical manifestation before COVID-19 infections in 19 primary immunodeficient patients
| Primary immunodeficiency categories | ID | PID diagnosis | Gender | Age of onset (m) | Age of PID diagnosis (m) | Infection | Autoimmunity | Lymphoproliferation | Other PID clinical manifestation | |
|---|---|---|---|---|---|---|---|---|---|---|
| Combined immunodeficiencies |
Non-syndromic combined immunodeficiencies |
P1 | SCID | F | 1 | 1 | URI, LRI | – | LAP | Sensitivity to light |
| P2 | SCID | M | 6 | 20 | LRI | – | – | – | ||
| P3 | SCID | M | 6 | 6 | LRI | – | – | – | ||
| P4 | Omenn syndrome | M | 1.5 | 2.5 | BCGosis, LRI | – | LAP | Severe scaling erythematous skin lesions | ||
| P5 | CID | M | 4 | 11 | LRI | AIT | LAP | – | ||
| P6 | STK4 | M | 108 | 108 | Meningitis, cellulitis | ITP, AIHA | LAP | Seizure, neurological disorders | ||
| Syndromic combined immunodeficiencies | P7 | WAS | M | 4 | 4 | LRI | – | – | Chronic diarrhea, microcytic thrombocytopenia | |
| P8 | ATM | M | 24 | 108 | URI, LRI | – | – | Ataxic gait, telangiectasia | ||
| P18 | DNMT3B | M | 10 | 17 | URI, LRI | – | LAP | Recurrent diarrhea | ||
| P19 | DNMT3B | F | 15 | 28 | URI, LRI | – | – | Recurrent diarrhea, bronchiectasis | ||
| Predominantly antibody deficiencies | P9 | BTK | M | 36 | 48 | Skin infection, URI, LRI | – | – | Urticaria, erythematous skin lesions | |
| P10 | CVID | M | 12 | 240 | OME, LRI | ITP, AIHA, JIA | – | Recurrent diarrhea, bronchiectasis | ||
| P11 | HIgM | F | 36 | 72 | OME, LRI, osteomyelitis | – | HSM | FTT, granulomatous inflammatory process in BM | ||
| P12 | SIgAD | M | 6 | 84 | OME, LRI, recurrent oral herpes lesions | – | – | Bronchiectasis | ||
| Congenital defects of phagocytes | P13 | CGD | F | 36 | 36 | LRI | – | – | FTT | |
| P14 | CYBA | M | 1 | 120 | URI, LRI | – | Pulmonary granulomatosis lesion | Bronchiectasis severe pulmonary fibrosis | ||
| Diseases of immune dysregulation | P15 | RAB27A | F | 60 | 106 | URI, LRI | AIHA | HSM | Albinism, gray hair, severe anal ulcer, hemophagocytic BM | |
| P16 | CD70 | F | 84 | 108 | URI, LRI | Behcet’s disease, alopecia | HSM | HL | ||
| Autoinflammatory disorders | P17 | IL1RN | F | 1 | 4 | Cellulitis, dental abscess, gingivitis | UC | HSM | Rash and skin lesions, edema in the right shoulder, chronic diarrhea, severe generalized erythroderma, ascites, anemia, femur swelling | |
SCID severe combined immunodeficiency, CID combined immunodeficiency, STK4 serine/threonine kinase 4 gene, WAS WASP actin nucleation promoting factor gene, ATM ataxia-telangiectasia mutated gene, BTK Bruton’s tyrosine kinase gene, CYBA cytochrome B-245 alpha chain gene, RAB27A RAS-associated protein 27A gene, CD70 tumor necrosis factor ligand family cluster of differentiation 70 gene, IL1RN interleukin 1 receptor antagonist gene, CVID common variable immunodeficiency, HIgM hyper IgM syndrome, SIgAD selective immunoglobulin A deficiency, CGD chronic granulomatous disease, LRI lower respiratory infections, URI upper respiratory infections, OME otitis media with effusion, AIT autoimmune hypothyroidism, JIA juvenile idiopathic arthritis, AIHA autoimmune hemolytic anemia, ITP immune thrombocytopenic purpura, UC ulcerative colitis, LAP lymphadenopathy, SM splenomegaly, HM hepatomegaly, HSM hepatosplenomegaly, FTT failure to thrive, BM bone marrow aspiration/biopsy, HL Hodgkin’s lymphoma, F female, M male