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. 2020 Oct 27;9:e56098. doi: 10.7554/eLife.56098

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© 2020, Kumar Bharathkar et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 4. — (A) Cartoon representations of an unliganded mouse SC homology model based on unliganded human SC crystal structure (PDB code 5D4K; left) and the dIgA-bound mouse SC (right). The dIgA is shown as a molecular surface representation; SC domains D1-D5 are show in color gradient from cyan (D1) to pale green (D5), with CDR loops colored gray; PNGS are shown as orange spheres. Regions where SC interfaces with dIgA and other SC domains are boxed. (B-D) Boxed, enlarged views of stabilizing interfaces between SC Fc, JC and other SC domains; colored as in panel A. (B) SC D1 interface with C_H3_A, C_H3_B, Tp_C, Tp_D. (C) SC D1-D3 interface. (D) SC D4-D5 interface with JC and C_H2_C. In all panels conserved, interfacing residues are shown as sticks and hydrogen bonds and salt bridges are show as black dashes.