Table 2. Comparison of different studies that evaluate the different effects of SSRIs on EAE animals.

YOP: year of publication; SSRI: selective serotonin reuptake inhibitor; EAE: experimental autoimmune encephalopathy; IFN-γ: interferon gamma; TNF: tumor necrosis factor; IL: interleukin

Title	Author	YOP	Purpose of the study	Conclusions
The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis	Taler et al. [25]	2011	Evaluate the immunosuppressive capacity of sertraline in EAE animals	Sertraline was able to slow the progression of the disease and ameliorate some of the symptoms and decrease the synthesis of multiple cytokines like IFN, TNF, and IL-2 after the infusion of the drug
Fluoxetine promotes remission in acute experimental autoimmune encephalomyelitis in rats	Yuan et al. [24]	2012	Determine the effects of fluoxetine used prophylactically in EAE animals	Fluoxetine effects: suppression of IFN-γ synthesis; decreased the number of inflammatory lesions on the CNS and the demyelination degree
Amelioration of ongoing experimental autoimmune encephalomyelitis with fluoxetine	Bhat et al. [26]	2017	Determine the action of fluoxetine as in immune modulator	Fluoxetine was able to suppress the synthesis of inflammatory cytokines (TNF-α, IL-6, and IL-10) and decrease the intensity and frequency of symptoms; induced cell death on T lymphocytes
Fluvoxamine stimulates oligodendrogenesis of cultured neural stem cells and attenuates inflammation and demyelination in an animal model of multiple sclerosis	Ghareghani et al. [8]	2017	Evaluation of the effects of fluvoxamine in EAE animals	Fluvoxamine could act on neural stem cells: augmented the viability of these cells and their proliferation capacity; induced conversion into oligodendrocytes; decreased clinical scores, inflammatory foci, and demyelinated areas after the SSRI treatment; decreased IFN-γ synthesis; increased IL-4