Table 3.
Comparison of plasma PCO levels in PD and HD.
| Study year | Number of HD or PD patients (age and sex) and dialysis vintage | Number of control healthy subjects (age and sex) | Analytical methods | Plasma PCO in HD or PD patients | Plasma PCO in control subjects | p value |
|---|---|---|---|---|---|---|
| Tbahriti et al. 2013 [50] | (A) 40 HD patients (age 42 ± 11 years, 22 M and 18 F) (B) 25 PD patients (age 39 ± 15 years) |
— | Spectrophotometric assay after derivatization with DNPH (commercial kit) | (A) HD patients 1.85 ± 0.16 nmol/mg albumin (B) HD patients 1.92 ± 0.13 nmol/mg albumin |
— | Statistical difference not specified |
|
| ||||||
| Erdoğan et al. 2002 [108] | (A) 7 HD patients (B) 9 PD patients (mean age 38.7 ± 12.9 years, 7 M and 9 F) |
(H) 9 age-matched healthy subjects (2 M and 7 F) | Spectrophotometric assay after derivatization with DNPH [142] | (A) HD patients 1.1 ± 0.2 nmol/mg protein (B) PD patients 1.1 ± 0.3 nmol/mg protein |
(H) 0.8 ± 0.3 nmol/mg protein | No significant variations |
|
| ||||||
| Doñate et al. 2002 [109] | (A) 21 HD patients (B) 42 PD patients |
— | ELISA after derivatization with DNPH [32] | (A) HD patients 0.1665 ± 0.04 nmol/mg protein (B) PD patients 0.1452 ± 0.03 nmol/mg protein |
— | (A) vs. (B) p < 0.004 |
|
| ||||||
| Mitrogianni et al. 2009 [44] | (A) 25 HD patients (age 26–80 years, 16 M and 9 F) (B) 21 PD patients (age 18–77 years, 13 M and 8 F) |
(H) 20 healthy subjects (age range 29–78 years, 12 M and 8 F) | Western blot analysis after derivatization with DNPH (commercial kit) | (A) HD patients densitometric units (B) PD patients densitometric units |
Control densitometric units Control densitometric units |
(A) vs. (H) p < 0.05 |
|
| ||||||
| Mekki et al. 2010 [110] | (A) 20 HD patients (age 36 ± 12 years, 8 M and 12 F) HD vintage 12-60 months (B) 20 PD patients (age 40 ± 8 years, 10 M and 10 F) PD vintage 3-48 months |
— | Spectrophotometric assay after derivatization with DNPH [141] | (A) HD patients 0.92 ± 0.15 μmol∗mL (B) PD patients 1.90 ± 0.10 μmol∗mL |
— | (A) vs. (B) p < 0.01 |
|
| ||||||
| Guo et al. 2011 [111] | (A) 45 PD patients (age 54 ± 9 years, 22 M and 23 F) PD vintage 2.4 ± 1.1 years |
(H) 30 healthy subjects (age 52 ± 7 years, 12 M and 18 F) | Spectrophotometric assay after derivatization with DNPH [141] | (A) PD patients 0.42 ± 0.23 nmol/mg protein | (H) 0.16 ± 0.08 nmol/mg protein | (A) vs. (H) p < 0.05 |
|
| ||||||
| Tbahriti et al. 2013 [50] | (A) 40 HD patients (age 42 ± 11 years, 22 M and 18 F) HD vintage 14-109 months (B) 25 PD patients (age 39 ± 15 years, 12 M and 13 F) PD vintage 5-49 months |
— | Spectrophotometric assay after derivatization with DNPH (commercial kit) | (A) HD patients 1.85 ± 0.16 nmol/mg protein (B) PD patients 1.92 ± 0.13 nmol/mg protein |
— | |
Data are presented as the mean ± standard deviation (SD), in the reported studies. M: male: F: female; CKD: chronic kidney disease; ESRD: end-stage renal disease; HD: haemodialysis (haemodialysed); PCO: protein carbonyls (carbonylated proteins); DNPH: 2,4-dinitrophenylhydrazine; PD: peritoneal dialysis.