Table 3. Multiple regression analysis of the BPD-related factors in very low birth weight infants with CHD.
| Variable | Moderate-to-severe BPD | p value | Moderate-to-severe BPD | p value | Severe BPD | p value | Severe BPD | p value |
|---|---|---|---|---|---|---|---|---|
| Crude OR (95% CI) | OR (95% CI) | Crude OR (95% CI) | OR (95% CI) | |||||
| Gestational age (weeks) | 0.98 (0.95–1.00) | 0.125 | 0.97 (0.94–1.00) | 0.052 | ||||
| Birth weight (g) | 0.99 (0.99–1.00) | 0.470 | 1.00 (0.99–1.00) | 0.766 | ||||
| Male (sex) | 1.02 (0.39–2.68) | 0.954 | 0.98 (0.34–2.84) | 0.975 | ||||
| Cesarean delivery | 1.33 (0.38–4.59) | 0.648 | 0.54 (0.15–1.94) | 0.492 | ||||
| Chorioamnionitis | 1.82 (0.49–6.76) | 0.505 | 1.95 (0.488–7.81) | 0.445 | ||||
| PIH | 3.14 (0.84–11.7) | 0.079 | 2.25 (0.61–8.31) | 0.284 | ||||
| SGA (<10th percentile) | 0.61 (0.23–1.62) | 0.329 | 0.47 (0.160–1.41) | 0.177 | ||||
| Antenatal steroid | 0.71 (0.25–2.03) | 0.528 | 0.61 (0.20–1.91) | 0.402 | ||||
| RDS | 1.34 (0.50–3.53) | 0.552 | 3.23 (1.07–9.71) | 0.033 | 2.60 (0.42–15.78) | 0.299 | ||
| Invasive MV (days) | 1.05 (1.01–1.08) | 0.002 | NA | NA | 1.07 (1.03–1.12) | <0.001 | NA | NA |
| Total MV (days) | 1.05 (1.02–1.09) | <0.001 | NA | NA | 1.11 (1.05–1.18) | <0.001 | NA | NA |
| Oxygen use period (days) | 1.06 (1.03–1.09) | <0.001 | 1.06 (1.02–1.09) | <0.001 | 1.05 (1.02–1.08) | <0.001 | 1.04 (1.01–1.07) | 0.003 |
| Cyanotic CHD | 4.92 (1.37–17.60) | 0.014 | 1.80 (0.33–9.89) | 0.495 | 9.77 (2.68–35.55) | <0.001 | 9.62 (1.48–62.55) | 0.018 |
| Late-onset sepsis | 6.54 (1.27–33.66) | 0.025 | 1.93 (0.22–16.66) | 0.547 | 8.94 (2.00–39.85) | 0.004 | 5.80 (0.77–43.48) | 0.087 |
BPD = bronchopulmonary dysplasia; CHD = congenital heart disease; CI = confidence interval; MV = mechanical ventilator; NA = not applicable; OR = odds ratio; PIH = pregnancy-induced hypertension; RDS = respiratory distress syndrome; SGA = small for gestational age.