Table 2.

List of identified proteins from MALDI-TOF MS/MS analyses, which are differentially expressed in plasma of CAD patients with respect to healthy control. For statistical evaluation, p < 0.05 was used as a significance threshold during the Mascot search database and uniProt database (http://www.uniprot.org/) that were searched for the protein function. Annotation: MALDI-TOF MS/MS: matrix-assisted laser desorption/ionization mass spectrometry; M.W.: molecular weight; Da: Dalton.

Spot no.	Proteins identified	Accession no.	M.W. (Da)	Peptide matched	Score	Biological functions
1	Keratin type I cytoskeletal 10	P13645	59020	4	88	Structural constituent of epidermis, cornification, keratinization, and keratinocyte differentiation.
2	Hemopexin	P02790	52385	3	75	Cellular iron ion homeostasis, Hemoglobin metabolic process, and metal ion binding.
3	Hemopexin	P02790	52385	3	136	Cellular iron ion homeostasis, along with the heme metabolic process and metal ion binding.
4	Haptoglobin	P00738	45861	3	75	Antioxidant activity and hemoglobin-binding protein involved in the acute-phase response and defense response. Additionally, the vital role in negative regulation of the oxidoreductase activity has been noted.
5	Haptoglobin	P00738	45861	4	91	Antioxidant activity and hemoglobin-binding protein involved in the acute-phase response and defense response. Additionally, the vital role in negative regulation of the oxidoreductase activity has been noted.
6	Fibrinogen alpha chain	P02671	94971	3	92	Blood coagulation, cell-matrix adhesion, cellular protein complex assembly, response to calcium ion.
7	Serotransferrin	P02787	79294	2	57	Cellular iron ion homeostasis and import ferrous iron into the cell. Additionally, transferrin regulates protein stability and transport transferrin.
8	Alpha-1-anti trypsin	P01009	46878	3	47	It is a well-known inhibitor of serine proteases and has a moderate affinity for plasmin and thrombin. Additionally, it inhibits trypsin, chymotrypsin, and plasminogen activator.
9	Alpha-1-anti trypsin	P01009	46878	4	107	It is a well-known inhibitor of serine proteases and has a moderate affinity for plasmin and thrombin. Additionally, it inhibits trypsin, chymotrypsin, and plasminogen activator.
10	Alpha-1-anti trypsin	P01009	46878	3	90	It is a well-known inhibitor of serine proteases and has a moderate affinity for plasmin and thrombin. Additionally, it inhibits trypsin, chymotrypsin, and plasminogen activator.
11	Alpha-1-anti trypsin	P01009	46878	3	61	It is a well-known inhibitor of serine proteases and has a moderate affinity for plasmin and thrombin. Additionally, it inhibits trypsin, chymotrypsin, and plasminogen activator.
12	Fibrinogen-alpha chain	P02671	94971	2	70	Fibrin has a major function in hemostasis as one of the primary components of blood clots and wound repair. Additionally, it also guides cell migration during reepithelialization.
13	Fibrinogen-gamma chain	P02679	52106	2	59	Blood coagulation, cell-matrix adhesion, cellular protein complex assembly, response to calcium ion.
14	Keratin type I cytoskeletal 10	P13645	59020	8	255	It is a structural constituent of epidermis and cornification that plays role in keratinization and keratinocyte differentiation.
15	Keratin type I cytoskeletal 10	P13645	59020	4	88	It is a structural constituent of epidermis and cornification that plays role in keratinization and keratinocyte differentiation.
16	Apolipoprotein A-I	P02647	30759	16	98	The major contribution of apo family proteins has been reported in cholesterol biosynthetic and metabolic process and also involves in high-density lipoprotein particle modelling.
17	Transthyretin	P02766	15991	5	80	It is involved in the cellular and retinoid metabolic process with dual binding ability. It has also organized extracellular matrix, identical protein binding, and thyroid hormone binding activities.
18	Talin-1	Q9Y490	240120	26	45	Talin-1 plays varied function such as actin filament binding, cadherin binding, integrin binding, phosphatidylinositol binding, and phosphatidylserine binding.
19	Alpha-2HS-glycoprotein	P02765	64214	12	36	Alpha-2HS-glycoprotein has the potential to involved in the kinase inhibitor activity, cellular protein metabolic process, regulation of inflammatory response, platelet degranulation, and neutrophil degranulation.