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. 2020 Aug 18;48(21):11827–11844. doi: 10.1093/nar/gkaa670

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Chemically stabilized siRNA survives for weeks in acidic intracellular compartments. An Advanced ESC GalNAc–siRNA (siTTR-2) targeting Ttr was dosed SC at 0.5 mg/kg (all cohorts including the control group, which is shown in each graph as a comparison). GalNAc-INF7 endolytic peptide was dosed SC at 5 mg/kg in cohorts of mice at either 8 h (A) or days 11 (B), 14 (C) or 21 (D) post siRNA dose. Serum TTR protein levels were monitored through day 45. Data is represented as mean ± SD, for N = 3. Welch's independent t-test was utilized to compare the mean value between the control and peptide-treated groups at each timepoint to identify significant differences in target knockdown(*P ≤ 0.05, **P ≤ 0.01). Full results for the statistical analysis are included in the Supplemental Information.