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. 2020 Oct 19;48(21):e123. doi: 10.1093/nar/gkaa872

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 9. — Allele-specific Hi-C chromatin maps and ChIA-PET loops in human GM12878 cells. ASHIC-imputed allelic contact maps are shown at 10 kb resolution (top panel: maternal allele, red color key; bottom panel: paternal allele, blue color key). Phased ChIA-PET loops and SNPs with haplotype-biased ChIA-PET bindings are obtained from Tang et al. (17). (A) H19/IGF2 imprinting region. Maternal-enriched and paternal-enriched chromatin interacting regions are labeled in red and blue boxes, respectively. Vertical dashed lines indicate (sub-)TAD boundaries. (B) Allelic long-range enhancer-promoter interactions at LOC374443, CLEC2D and CLECL1 genes. Blue box indicates the paternal-enriched chromatin interacting region. The distal enhancer associated with paternal-biased RNAPII-mediated ChIA-PET loops is highlighted in blue. Both panels are drawn using pyGenomeTracks (28).