Fig. 4.

Isabl applications enable systematic processing of experimental data. a Guided by metadata, Isabl applications construct, validate, and deploy computing commands across experiments. Applications differ from Workflow Management Systems in that they don't execute the analytical logic but construct and submit a command. b Isabl applications can be assembly aware, this means that they can be versioned not only as a function of their name, but also as a function of the genome assembly they are configured for. This is important because NGS results are comparable when produced with the same genome version. The unique combination of targets and references, such as tumor-normal pairs, results in analyses. The figure panel illustrates applications with different experimental designs, such as paired analyses, multi-targets, single-target, etc. Importantly, applications are agnostic to the underlying tool or pipeline being executed