Table 1.
Patients and primary colorectal tumor characteristics in each group (initial and second pulmonary metastasectomy)
| Characteristics | The initial pulmonary metastasectomy n = 126 |
The second pulmonary metastasectomy n = 26 |
p value |
|---|---|---|---|
| Gender, n (%) |
Male 85 (67.5) Female 41 (32.5) |
Male 16 (61.5) Female 10 (38.5) |
0.56 |
| Age¶, median [range] | 66 [37–84] | 62.5 [37–77] | 0.04* |
| Smoking habits, n (%) | Non-smoker 39 (31.0) Smoker 79 (62.7) |
Non-smoker 10 (38.5) Smoker 13 (50.0) |
0.34 |
| Brinkman index✝, median [range] | 457.5 [0–2100] | 107 [0–2000] | 0.46 |
| Primary colorectal tumor location, n (%) |
Colon 59 (46.8) Rectum 66 (52.4) |
Colon 11 (42.3) Rectum 16 (57.7) |
0.65 |
|
Right side 23 (18.2) Left side 102 (81.0) |
Right side 3 (11.5) Left side 23 (88.5) |
0.38 | |
| Histological differentiation of the primary colorectal tumor, n (%) |
Well–55 (43.6) Moderately–53 (42.0) Poorly–6 (4.8) |
Well–8 (30.8) Moderately–9 (34.6) Poorly–1 (3.8) |
0.54 |
| Pathological T stage‡, n (%) |
T1 7 (5.6) T2 11 (8.7) T3 61 (48.4) T4 37 (29.4) |
T1 1 (3.8) T2 0 (0.0) T3 15 (57.7) T4 6 (23.1) |
0.19 |
| Pathological N stage‡, n (%) |
N0 43 (34.1) N1 47 (37.3) N2 24 (19.0) |
N0 7 (27.0) N1 9 (34.6) N2 5 (19.2) |
0.92 |
| Pathological stage‡, n (%) |
I 8 (6.3) II 25 (19.8) III 56 (44.4) IV 31 (24.6) |
I 0 (0.0) II 5 (19.2) III 12 (46.2) IV 8 (30.8) |
0.35 |
| Past history of extra thoracic metastasis, n (%) |
Present 45 (35.7) Absent 81 (64.3) |
Present 10 (38.5) Absent 16 (61.5) |
0.79 |
| Adjuvant chemotherapy, n (%) | Yes 61 (48.4) No 57 (45.2) | Yes 16 (61.5) No 8 (30.8) | 0.18 |
| Regimen, n (%) |
UFT 28 (22.2) capecitabine 7 (5.6) CapeOX 7 (5.6) FOLFOX 5 (4.0) S1 4 (3.2) FU + LV 3 (2.4) Other 7 (5.6) |
UFT 5 (19.2) FOLFOX 3 (11.5) Capecitabine 2 (7.7) CapeOX 1 (3.8) FU + LV 1 (3.8) Other 4 (15.4) |
– |
| Number of pulmonary metastasectomy, n (%) | – |
2 times 14 (53.9) 3 times 7 (26.9) 4 times 5 (19.2) |
– |
¶: Age at the initial pulmonary metastasectomy
✝: Brinkman index = (the number of cigarette smoked per day) × (the number of years of smoking)
‡: UICC TNM classification(the 8th edition)
*p < 0.05; **p < 0.01; ***p < 0.001