Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 30;18:188. doi: 10.1186/s12964-020-00678-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Histological analysis of knee joint tissue from CAIA mice. a Appearance of wild type mice with or without experimental arthritis (CAIA). b Sections of normal (left) and CAIA (right) knee joints stained with Hematoxylin and Eosin showing hyperplastic synovium (HS) in the joint (arrow head). Scale bar represents 500 μm. In immunofluorescent staining c F4/80-positive (green) cells were observed in the HS and articular cavity (AC). The inflammatory macrophage markers Nos2 and Tnf (red) co-localized in F4/80^high-positive cells (arrow, yellow). Scale bar represents 20 μm. d Synovial cells were localized randomly in the HS. Panels on the right are high magnification images of boxed areas in the left panels. Podoplanin (Pdpn)-positive (red) cells were also observed in the HS. Scale bar represents 50 μm (left panel) and 20 μm (right panel). Histological data were technically replicated more than 2 times