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. 2020 Nov 30;18:455. doi: 10.1186/s12967-020-02629-w

Table 3.

Incidence rate ratio and hazard ratio of Parkinson's disease and ankylosing spondylitis cohort to non-ankylosing spondylitis cohort

Variables Ankylosing spondylitis Crude HR (95%CI) Adjusted HR
(95%CI)
No
(N = 25,760)
Yes
(N = 6440)
event Person years rate event Person years rate
Sex
 Male 111 82,421 1.35 52 20,957 2.48 1.85 (1.33, 2.57)*** 1.66 (1.19, 2.32)**
 Female 99 88,437 1.12 50 22,295 2.24 2.01 (1.43, 2.82)*** 1.85 (1.31, 2.62)***
Age, years
  ≤ 49 11 100,196 0.11 14 25,575 0.55 4.99 (2.26, 11.0)*** 4.70 (2.10, 10.5)***
 50–64 50 44,307 1.13 21 11,120 0.89 1.68 (1.01, 2.80)* 1.32 (0.78, 2.21)
 ≥ 65 149 26,356 5.65 67 6557 10.2 1.80 (1.35, 2.40)*** 1.69 (1.26,2.26)***
Comorbidity
 No 46 114,349 0.40 22 24,374 0.90 2.25 (1.35, 3.74)** 2.71 (1.63, 4.50)***
 Yes 164 56,509 2.90 80 18,878 4.24 1.47 (1.12, 1.92)** 1.61 (1.23, 2.10)***

Rate per 1000 person-year; Crude HR, relative hazard ratio

Model was adjusted for age and comorbidities of diabetes, hypertension, hyperlipidemia, stroke, depression, coronary artery disease, head injury, and chronic kidney disease and medication of NSAIDs

Patients with any one of the comorbidities (diabetes, hypertension, hyperlipidemia, stroke, depression, coronary artery disease, head injury, chronic kidney disease and epilepsy) were classified as the comorbidity group

*p < 0.05, **p < 0.01, ***p < 0.001