Table 3.
Incidence rate ratio and hazard ratio of Parkinson's disease and ankylosing spondylitis cohort to non-ankylosing spondylitis cohort
Variables | Ankylosing spondylitis | Crude HR (95%CI) | Adjusted HR† (95%CI) |
|||||
---|---|---|---|---|---|---|---|---|
No (N = 25,760) |
Yes (N = 6440) |
|||||||
event | Person years | rate | event | Person years | rate | |||
Sex | ||||||||
Male | 111 | 82,421 | 1.35 | 52 | 20,957 | 2.48 | 1.85 (1.33, 2.57)*** | 1.66 (1.19, 2.32)** |
Female | 99 | 88,437 | 1.12 | 50 | 22,295 | 2.24 | 2.01 (1.43, 2.82)*** | 1.85 (1.31, 2.62)*** |
Age, years | ||||||||
≤ 49 | 11 | 100,196 | 0.11 | 14 | 25,575 | 0.55 | 4.99 (2.26, 11.0)*** | 4.70 (2.10, 10.5)*** |
50–64 | 50 | 44,307 | 1.13 | 21 | 11,120 | 0.89 | 1.68 (1.01, 2.80)* | 1.32 (0.78, 2.21) |
≥ 65 | 149 | 26,356 | 5.65 | 67 | 6557 | 10.2 | 1.80 (1.35, 2.40)*** | 1.69 (1.26,2.26)*** |
Comorbidity‡ | ||||||||
No | 46 | 114,349 | 0.40 | 22 | 24,374 | 0.90 | 2.25 (1.35, 3.74)** | 2.71 (1.63, 4.50)*** |
Yes | 164 | 56,509 | 2.90 | 80 | 18,878 | 4.24 | 1.47 (1.12, 1.92)** | 1.61 (1.23, 2.10)*** |
Rate per 1000 person-year; Crude HR, relative hazard ratio
†Model was adjusted for age and comorbidities of diabetes, hypertension, hyperlipidemia, stroke, depression, coronary artery disease, head injury, and chronic kidney disease and medication of NSAIDs
‡Patients with any one of the comorbidities (diabetes, hypertension, hyperlipidemia, stroke, depression, coronary artery disease, head injury, chronic kidney disease and epilepsy) were classified as the comorbidity group
*p < 0.05, **p < 0.01, ***p < 0.001