Table 3.
Markers | Categories | All stages | Stage I and II | Stage III | Stage IV | P for interaction | ||||
---|---|---|---|---|---|---|---|---|---|---|
ndeath/ncases | HR (95% CI)* | ndeath/ncases | HR (95% CI)# | ndeath/ncases | HR (95% CI)# | ndeath/ncases | HR (95% CI)# | |||
AgeAccelHorvath | Tertile 1 | 361/736 | 1.00 (Ref.) | 135/364 | 1.00 (Ref.) | 124/260 | 1.00 (Ref.) | 100/107 | 1.00 (Ref.) | – |
Tertile 2 | 339/736 | 1.01 (0.86, 1.18) | 138/402 | 0.97 (0.76, 1.24) | 109/236 | 0.95 (0.73, 1.25) | 87/92 | 1.14 (0.83, 1.55) | – | |
Tertile 3 | 379/734 | 1.17 (0.99, 1.38) | 163/393 | 1.32 (1.04, 1.38) | 117/230 | 1.18 (0.90, 1.55) | 98/110 | 0.98 (0.71, 1.34) | – | |
Per SD increase | 1079/2206 | 1.06 (0.99, 1.13) | 436/1159 | 1.10 (0.99, 1.21) | 350/726 | 1.10 (0.99, 1.23) | 285/309 | 0.96 (0.84, 1.10) | 0.139 | |
AgeAccelHannum | Tertile 1 | 327/736 | 1.00 (Ref.) | 128/386 | 1.00 (Ref.) | 124/268 | 1.00 (Ref.) | 74/80 | 1.00 (Ref.) | – |
Tertile 2 | 340/736 | 0.93 (0.78, 1.09) | 126/387 | 0.89 (0.69, 1.15) | 109/235 | 0.93 (0.70, 1.24) | 103/111 | 0.86 (0.60, 1.24) | – | |
Tertile 3 | 412/734 | 1.12 (0.94, 1.33) | 182/386 | 1.18 (0.91, 1.53) | 117/223 | 1.14 (0.84, 1.55) | 108/118 | 0.91 (0.62, 1.34) | – | |
Per SD increase | 1079/2206 | 1.06 (0.98, 1.14) | 436/1159 | 1.05 (0.93, 1.17) | 350/726 | 1.11 (0.98, 1.26) | 285/309 | 1.00 (0.86, 1.17) | 0.475 | |
DNAmMRscore | Tertile 1 | 275/736 | 1.00 (Ref.) | 102/410 | 1.00 (Ref.) | 97/242 | 1.00 (Ref.) | 76/84 | 1.00 (Ref.) | |
Tertile 2 | 346/736 | 1.07 (0.89, 1.30) | 147/399 | 1.27 (0.94, 1.70) | 104/231 | 0.97 (0.71, 1.34) | 92/102 | 0.89 (0.61, 1.29) | ||
Tertile 3 | 458/734 | 1.66 (1.32, 2.09) | 187/350 | 2.01 (1.42, 2.85) | 149/253 | 1.64 (1.13, 2.38) | 117/123 | 1.33 (0.87, 2.04) | – | |
Per SD increase | 1079/2206 | 1.34 (1.20, 1.49) | 436/1159 | 1.50 (1.28, 1.76) | 350/726 | 1.39 (1.18, 1.64) | 285/309 | 1.09 (0.90, 1.33) | 0.616 | |
AgeAccelPheno | Tertile 1 | 318/736 | 1.00 (Ref.) | 122/390 | 1.00 (Ref.) | 123/263 | 1.00 (Ref.) | 71/80 | 1.00 (Ref.) | – |
Tertile 2 | 323/736 | 1.02 (0.86, 1.20) | 126/395 | 0.89 (0.68, 1.15) | 99/234 | 0.92 (0.69, 1.22) | 96/102 | 1.43 (1.02, 2.01) | – | |
Tertile 3 | 438/734 | 1.35 (1.14, 1.59) | 188/374 | 1.50 (1.17, 1.92) | 128/229 | 1.28 (0.98, 1.69) | 118/127 | 1.31 (0.93, 1.86) | – | |
Per SD increase | 1079/2206 | 1.18 (1.10, 1.27) | 436/1159 | 1.22 (1.11, 1.35) | 350/726 | 1.20 (1.07, 1.35) | 285/309 | 1.12 (0.97, 1.30) | 0.459 | |
AgeAccelGrim | Tertile 1 | 286/736 | 1.00 (Ref.) | 98/405 | 1.00 (Ref.) | 119/258 | 1.00 (Ref.) | 68/72 | 1.00 (Ref.) | – |
Tertile 2 | 347/736 | 1.13 (0.94, 1.34) | 144/381 | 1.34 (1.00, 1.78) | 106/246 | 0.98 (0.73, 1.32) | 95/104 | 0.95 (0.66, 1.37) | – | |
Tertile 3 | 446/734 | 1.65 (1.37, 2.00) | 194/373 | 2.30 (1.69, 3.13) | 125/222 | 1.63 (1.19, 2.22) | 122/133 | 1.01 (0.71, 1.45) | – | |
Per SD increase | 1079/2206 | 1.35 (1.24, 1.47) | 436/1159 | 1.48 (1.31, 1.66) | 350/726 | 1.24 (1.08, 1.43) | 285/309 | 1.23 (1.05, 1.44) | 0.082 |
AgeAccel, age acceleration; CI, confidence interval; DNAm, DNA methylation; HR, hazard ratio; MRscore, mortality risk score
Numbers printed in bold: statistically significantly different from 1 (P < 0.05)
*Overall HR was adjusted for age, sex, batch effects, tumor stage and leukocyte composition (Houseman’s algorithm)
#Stage-specific HR was adjusted for age, sex, batch effects and leukocyte composition (Houseman’s algorithm)