Table 5.
Harrell’s C-statistics (95% CI) for all-cause mortality and CRC-specific mortality prediction
| Outcomes | Models | All stages | Stage I and II | Stage III | Stage IV |
|---|---|---|---|---|---|
| All-cause mortality | Common predictors* | 0.739 (0.723, 0.754) | 0.693 (0.667, 0.719) | 0.653 (0.622, 0.683) | 0.557 (0.520, 0.594) |
| +DNAmMRscore# | 0.747 (0.732, 0.762) | 0.709 (0.684, 0.735) | 0.668 (0.638, 0.698) | 0.592 (0.554, 0.629) | |
| +AgeAccelPheno# | 0.746 (0.731, 0.761) | 0.708 (0.683, 0.734) | 0.662 (0.632, 0.692) | 0.587 (0.552, 0.623) | |
| +AgeAccelGrim# | 0.754 (0.740, 0.769) | 0.725 (0.700, 0.749) | 0.671 (0.641, 0.700) | 0.589 (0.551, 0.627) | |
| CRC-specific mortality | Common predictors* | 0.809 (0.792, 0.825) | 0.612 (0.559, 0.666) | 0.608 (0.568, 0.648) | 0.557 (0.519, 0.595) |
| +DNAmMRscore# | 0.815 (0.798, 0.831) | 0.633 (0.582, 0.685) | 0.635 (0.595, 0.675) | 0.589 (0.551, 0.627) | |
| +AgeAccelPheno# | 0.813 (0.797, 0.829) | 0.636 (0.584, 0.688) | 0.621 (0.582, 0.660) | 0.586 (0.549, 0.623) | |
| +AgeAccelGrim# | 0.814 (0.798, 0.830) | 0.646 (0.596, 0.697) | 0.626 (0.586, 0.665) | 0.584 (0.545, 0.623) |
AgeAccel, age acceleration; CI, confidence interval; MRscore, DNA methylation mortality risk score
*Common predictors include age, sex, tumor stage for overall C-statistics, and age and sex for stage-specific C-statistics
#Models include common predictors and the corresponding DNA methylation aging algorithm