Table 1.
Timeline and milestones for clinical recovery, including date of initial injury and prior longitudinal studies with TG
| Research timeline | Date | Clinical milestones |
|---|---|---|
| Phase 1: Motor fMRI Study (D'Arcy et al. 2016) | 2006/03 | Initial injury. Prognosis: permanent vegetative state |
| 2007/09 | Fully conscious | |
| 2007–2010 | Intensive physical therapy | |
| MRI 1 | 2010/05 | Stands at wall-mounted bar without safety harness |
| MRI 2 | 2010/08 | Takes steps inside parallel bar with harness and assistance |
| MRI 3 | 2010/11 | No longer needed lift to get into MRI machine |
| MRI 4 | 2011/02 | Stands and pivots with assistance |
| MRI 5 | 2011/05 | Stands for 2 min with knee blocks |
| MRI 6 | 2011/08 | Stands for 6 min with knee blocks and assistance |
| MRI 7 | 2011/11 | Stands for 10 min with knee blocks assistance |
| MRI 8 | 2012/02 | Stands for 30 s without knee blocks or assistance |
| MRI 9 | 2012/05 | Sits without support |
| MRI 10 | 2012/08 | Stands with walker |
| MRI 11 | 2012/11 | Takes steps inside parallel bar with assistance |
| MRI 12 | 2013/02 | Takes steps with walker with assistance |
| Phase 2: Current Study | 2012–2013 | PT with Lokomat device |
| 2014–2015 | PT with ReWalk exoskeleton device | |
| 2016–2018 | Plateau in Recovery | |
| 2018/04 | Intensive physical therapy treatment begins | |
| 1st baseline (B1) | 2018/07 |
2 min timed stand − moderate support FIST Score—13 |
| 2nd baseline (B2) | 2018/10 |
1 min timed stand − moderate support FIST Score—19 |
| 3rd baseline (B3) | 2019/04 |
FIST Score—12 Continued plateau in recovery coupled with lack of motivation and intensity |
| 2019/04 | Physical therapy + translingual neurostimulation begins | |
| 1st treatment assessment (T1) | 2019/05 |
20 min timed stand − moderate support FIST score—21 |
| 2nd treatment assessment (T2) | 2019/07 |
20 min timed stand − minimal support FIST Score—33 Deep breathing improved—was able to blow up a balloon for the first time Renewed motivation and intensity to engage in therapy activities |
| 2019+ | Ongoing physical therapy + translingual neurostimulation |