Table 3.
Contraindications to carbapenem sparing agents
| Antimicrobial | Total | Rash | Anaphylaxis | SCAR | Pregnancy | Heart failurea | Cirrhosis | Non-urinary tract source | Renal impairmente |
|---|---|---|---|---|---|---|---|---|---|
| Ceftolozane-tazobactam | 2 | 1 | 1 | 0 | – | – | – | – | – |
| Ceftazidime-avibactam | 2 | 1 | 1 | 0 | 0 | – | – | – | – |
| Plazomicinb | 42 | 0 | 0 | 0 | 0 | – | – | 26 | 21 |
| Fosfomycinc | 32 | 0 | 0 | 0 | – | 4 | 3 | 25 | 1 |
| Cefiderocold | 26 | 1 | 1 | 0 | 0 | – | – | 26 | – |
SCAR severe cutaneous adverse reaction
Excludes cases which tested resistant in vitro
a Includes both acute decompensated heart failure and NYHA IV heart failure
b 5 patients had both non-urinary tract source and renal impairment (eGFR < 30 mL/min/1.73 m2) as contraindications
c 1 patient had both cirrhosis and was dialysis dependent
d 2 patients had both allergy and non-urinary tract source
e Dialysis dependence for fosfomycin and eGFR < 30 mL/min/1.73 m2 for plazomicin