Table 1.
Affinity of Three Types of anti-PD-1 Antibodies [5]
| Sintilimab | Keytruda | Opdivo | |
|---|---|---|---|
| AUC inf (h· μg/mL) | 7846.554 | 8048.861 | 9349.858 |
| t 1/2 (h) | 35.623 | 42.453 | 43.505 |
| Cmax (ug/mL) | 218.519 | 224.217 | 238.710 |
| Vss (mL) | 1.262 | 1.527 | 1.299 |
| CL (mL/h) | 0.025 | 0.025 | 0.021 |
| Mean PD-1 receptor occupancy | >95% | NR | >70% |
| Kd (1/s) | 8.028E-5 | 4.090E+ 6 | 1.465E-3 |
| Ka (1/Ms) | 1.090E+ 6 | 4.090E+ 6 | 4.599E+ 5 |
t1/2 half-life, NR not reported, Kd dissociation constant, Vss volume of distribution at steady state, C max maximum observed concentration, CL clearance, AUC inf area under the serum concentration − time curve extrapolated to infinity (AUC all + C last /λ z), Ka association constant