Table 2.
Available Formoterol Products
| Formoterol Products | Brand Name | Delivery Method | Approvals | Dosage |
|---|---|---|---|---|
| Monotherapy products | ||||
| Formoterol | Atimos Modulite® | pMDI | EU | 12 μg BID; up to 4 inhalations daily for severe COPD |
| Formoterol inhalation powdera | Foradil Aerolizer® | Capsule used with Aerolizer inhaler | US 2001 EU |
12 μg every 12 hours |
| Formoterol inhalation solution | Perforomist® | Nebulizer | US 2001 | One 20 μg/2 mL vial every 12 hours |
| Combination with corticosteroid | ||||
| Mometasone-formoterol | Dulera® | pMDI | US 2010 (asthma only) |
No COPD indication |
| Beclomethasone-formoterol | Fostair® (EU) Fostex® (Poland) |
pMDI and DPI | EU | 100/6 μg per inhalation; 2 inhalations BID 100/6 μg per inhalation (dosing frequency not specified) |
| Budesonide-formoterol | Symbicort® Symbicort Turbohaler® Fobumix Easyhaler® |
pMDI DPI DPI |
US 2006 EU 2014 EU 2016 |
160/4.5 μg per inhalation; 2 inhalations BID 200/6 μg per inhalation; 2 inhalations BID 160/4.5 μg per inhalation; 2 inhalations BID |
| Combination with LAMA | ||||
| Glycopyrrolate-formoterol | Bevespi AEROSPHERE® | pMDI (co-suspension technology) | US 2016 EU 2018 |
9/4.8 μg per inhalation; 2 inhalations BID |
| Aclidinium-formoterol | Duaklir Pressair® Duaklir Genuair® |
DPI DPI |
US 2019 EU 2014 |
400/12 μg per inhalation; 1 inhalation BID 340/12 μg per inhalation; 1 inhalation BID |
| Triple therapy (LABA, LAMA, ICS) | ||||
| Budesonide-glycopyrrolate- formoterol | Breztri AEROSPHERE® | pMDI | US 2020 | 160/9/4.8 µg per inhalation; 2 inhalations BID |
| Beclomethasone-formoterol-glycopyrronium | Trimbow® | pMDI | EU 2017 | 100/6/10 μg per inhalation; 2 inhalations BID |
Note: aNo longer available.
Abbreviations: BID, twice daily; COPD, chronic obstructive pulmonary disease; DPI, dry powder inhaler; EU, European Union; ICS, inhaled corticosteroid; LABA, long-acting β2-agonist; LAMA, long-acting muscarinic antagonist; pMDI, pressurized metered-dose inhaler; US, United States.