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Knockout of miR-21 partially reverses angiotensin II (Ang II)-induced ERK/TGF-β/Smad activation. (A) Representative and (B–E) quantitative analysis of Western blots of miR-21 knockout (KO) on Ang II-induced ERK/TGF-β/Smad signaling in primary cardiac fibroblasts (CFs). Ang II induces the activation of ERK/TGF-β/Smad signaling in primary CFs. This effect could be reversed by the KO of miR-21. ***P < 0.001, ****P < 0.0001, n = 3 per group.
Abbreviation: ns, not significant.
