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. 2020 Nov 27;13:12269–12279. doi: 10.2147/OTT.S278954

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© 2020 Liu et al.

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Effect of interfering with the expression of miRNA let-7a-5p and BZW2 on apoptosis of liver cancer cells under drug treatment. Let-7a-5p and BZW2 affects apoptosis in Bel7404 and HepG2 cells treated with sorafenib. Compared with the control group, the cells that were treated with sorafenib alone and the sorafenib+shBZW2 group had increased apoptosis. After knocking let-7a-5p down, hepatocellular carcinoma cells reduced apoptosis and decreased sensitivity to sorafenib (A and C). Quantitative analysis of migration ability in Bel7404 cells (B). Quantitative analysis of migration ability in HepG2 cells (D). *Indicates that thedifference between the treated and control cells was statistically significant (P < 0.05).