Table 3.

Cox regression analyses of factors associated with CSS (including T4aN0, T4bN0, T1N1, T2N1, and T1Na).

Variable	Univariate analyses		Multivariate analyses
	HR (95%CI)	P	HR (95%CI)	P
Stage		<0.001		<0.001
T4aN0	1		1.956 (1.044–3.665)	0.036
T4bN0	1.199 (1.059–1.356)	0.004	2.588 (1.382–4.848)	0.003
T1N1	0.204 (0.156–0.267)	<0.001	0.478 (0.244–0.934)	0.031
T2N1	0.325 (0.272–0.388)	<0.001	0.743 (0.392–1.408)	0.362
T1N2a	0.421 (0.225–0.786)	0.007	1
Age (years)		<0.001		<0.001
≤65	1		1
>65	1.954 (1.730–2.206)		1.511 (1.326–1.721)
Race		0.035		<0.001
White	1		1
Black	1.161 (0.988–1.364)	0.069	1.422 (1.208–1.673)	<0.001
Other	0.840 (0.680–1.038)	0.107	0.953 (0.770–1.180)	0.660
Gender		0.001		0.129
Male	1		1
Female	1.210 (1.081–1.353)		1.092 (0.975–1.223)
Grade		<0.001		<0.001
Grade I/II	1		1
Grade III/IV	1.528 (1.346–1.734)	<0.001	1.342 (1.181–1.524)	<0.001
Unknown	1.079 (0.770–1.513)	0.659	1.298 (0.922–1.826)	0.135
Histology		0.017		0.464
Adenocarcinoma	1		1
Mucinous adenocarcinoma/signet ring cell carcinoma	1.231 (1.038–1.459)		0.938 (0.790–1.114)
No. of examined lymph nodes		<0.001		<0.001
<12	1		1
≥12	0.598 (0.523–0.682)		0.526 (0.460–0.601)
Chemotherapy		<0.001		<0.001
No/unknown	1		1
Yes	0.407 (0.360–0.459)		0.595 (0.522–0.678)