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The potential contribution of Granzyme B (GrB) to the inflammation and dysfunction of adipose tissue in obese subjects. GrB, produced by different adipose tissue infiltrating inflammatory cells, may contribute to the promotion of the apoptotic, inflammatory and extracellular matrix (ECM) remodeling processes occurring in adipose tissue in obesity, leading to adipose tissue fibrosis and dysfunction, and driving up to glyco-metabolic impairment.
