Table 3.
Correlation between Granzyme B (GrB) mRNA expression in visceral adipose tissue (VAT) and clinical and biochemical parameters in obese subjects (n = 85).
| Correlation coefficient | p-value | |
|---|---|---|
| Age (years) | 0.12 | 0.26 |
| Sex (M/F) | 0.28 | 0.41 |
| Body mass index (kg/m2) | 0.08 | 0.46 |
| Waist circumference (cm) | 0.04 | 0.74 |
| Systolic blood pressure (mmHg) | 0.26 | 0.019 |
| Diastolic blood pressure (mmHg) | 0.22 | 0.04 |
| Total cholesterol (mg/dl) | 0.18 | 0.12 |
| HDL- cholesterol (mg/dl) | 0.01 | 0.92 |
| LDL- cholesterol (mg/dl) | 0.15 | 0.20 |
| Triglycerides (mg/dl) | 0.10 | 0.37 |
| Fasting blood glucose (mg/dl) | 0.029 | 0.008 |
| Glycosylated hemoglobin (%) | 0.23 | 0.01 |
| Fasting blood insulin(IU/ml) | 0.11 | 0.59 |
| HOMA-IR | 0.16 | 0.64 |
| HOMA-β% | 0.13 | 0.61 |
| Aspartate aminotransferase (IU/l) | 0.04 | 0.71 |
| Alanine aminotransferase (IU/l) | 0.08 | 0.44 |
| Serum GrB levels (pg/ml) | 0.31 | 0.04 |
| Type 2 diabetes (%) | 0.31 | 0.04 |
| Impaired fasting glucose (%) | 0.43 | 0.01 |
| Metabolic syndrome (%) | 0.18 | 0.09 |
Bivariate correlation analyses (Spearman’s coefficient; GrB mRNA is considered as a continue variable).