Table 1.
Summarized data results observed in nondiabetic and diabetic mice infected with Pb18, with and without treatment with insulin.
| Effects of Pb18 infection in diabetic mice with and without insulin treatment | ||
|---|---|---|
| T1D | T1D + Insulin | |
| 24 hours – lungs | ||
| Leukocytes number | NS | Higher |
| IFN-γ levels | Lower | NS |
| IL-12 p70 levels | Lower | Higher |
| Infection Index – alveolar macrophages | ||
| 4 h | Reduced | NS |
| 12 h | Reduced | Augmented |
| 24 h | Reduced | Augmented |
| 45 days – lungs | ||
| Leukocytes number | NS | Higher |
| IFN-γ levels | Higher | Lower |
| IL-12 p70 levels | NS | NS |
| TNF-α:IL-10 ratio | Higher | Lower |
| Il4 relative expression. | Higher | Lower |
| Il6 relative expression | Higher | NS |
| VCAM-1 expression | NS | Higher |
Comparisons were made versus their respective control (infected nondiabetic mice for infected diabetic mice and diabetic nontreated mice for diabetic treated mice).