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. 2020 Nov 18;11:610010. doi: 10.3389/fimmu.2020.610010

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Copyright © 2020 Genardi, Visvabharathy, Cao, Morgun, Cui, Qi, Chen, Gapin, Berdyshev and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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iNKT and type II NKT cells produce IFN-γ after SA infection. (A, B) Representative FACS plots of IFN-γ production of iNKT (A) and type II NKT (B) cells at 1 dpi from B6 liver, cultured directly ex vivo. (C, D) Quantified % cytokine production, gated on iNKT cells (C) and type II NKT cells (D). (N=3–6 naïve, N=5–12 infected mice). (E) rtPCR of cytokine mRNA of type II NKT cells sorted from 4 dpi Jα18^-/- mouse pooled liver lymphocytes (N=10 mice) compared to sorted conventional CD4⁺NK1.1^- T cells from Jα18^-/- splenocytes (N=2 mice), data represented as cytokine mRNA levels relative to β-actin. Statistical analysis: (C–E) 2-way ANOVA. *p < 0.05; ***p < 0.001; ****p < 0.0001.