Table 2.
Mixed-effects generalised linear modeling showing the unadjusted, multivariable and bootstrapped multivariable effect estimates of co-variables on fractional anisotropy and mean diffusivity of the roots of the brachial plexus
DTI parameter | Experimental factors | Unadjusted coefficients (95% CI) | p value | Adjusted coefficients (95% CI) | p value | Resampled adjusted coefficients (95% CI) | Resampled p value |
---|---|---|---|---|---|---|---|
Fractional anisotropy | SNR | 0.0001 (− 0.0003, 0.0004) | 0.662 | 0.0001 (− 0.0001, 0.0004) | 0.257 | 0.0001 (− 0.001, 0.002) | 0.840 |
Age in years | 0.0003 (− 0.006, 0007) | 0.926 | 0.001 (0.001, 0.002) | 0.001 | 0.001 (− 0001, 0.003) | 0.236 | |
Number of diffusion directions | − 0.002 (− 0.005, 0001) | 0.183 | − 0.001 (− 0.002, − 0.001) | < 0.001 | − 0.001 (− 0.002, − 0.0004) | 0.002 | |
Echo time (ms) | 0.002 [0.00001, 0.004]) | 0.174 | a | a | a | a | |
b value (mm/s) | − 0.0004 (− 0.001, 0.0001) | 0.098 | a | a | a | a | |
Resolution (mm3) | 0.008 (0.003, 0.013) | 0.126 | a | a | a | a | |
Mean diffusivity (mm2/s × 10–3) | SNR | − 0.001 (− 0.003, 0.0005) | 0.154 | − 0.001 (− 0.003, 0) | 0.055 | − 0.001 (− 0.012, 0.01) | 0.799 |
Age in years | − 0.01 (− 0.03, 0.01) | 0.303 | − 0.025 (− 0.030, − 0.021) | < 0.001 | − 0.03 (− 0.042, − 0.01) | 0.003 | |
Number of diffusion directions | 0.005 (− 0003, 0013) | 0.234 | 0.001 (− 0.001, 0.002) | 0.238 | 0.001 (− 0.005, 0.006) | 0.723 | |
Echo time (ms) | − 0.012 (− 0.019, − 0.005) | 0.174 | a | a | a | a | |
b value (mm/s) | 0.001 (0.0004, 0.002) | 0.003 | a | a | a | a | |
Resolution (mm3) | 0.004 (0.002, 0.007) | 0.562 | a | a | a | a |
aExcluded due to multicollinearity