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. 2020 Nov 18;11:585731. doi: 10.3389/fimmu.2020.585731

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Copyright © 2020 Roe, Vierra-Green, Pyo, Geraghty, Spellman, Maiers and Kuang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Probe motif multiple sequence alignment of the human haplotypes. The informal haplotype name and GenBank accession number are in the first column. The consensus motif pattern with each abbreviated locus name is described in the bottom row. Some loci share motifs: KIR2DL1, KIR2DS1, KIR2DS2 (green); KIR2DL5A and KIR2DL5B (orange); KIR2DS3, KIR2DS4, and KIR2DS5 (yellow). Some gene names are combined when they align at the same locus: KIR2DL2 and KIR2DL3 (2DL2L3), KIR2DS3 and KIR2DS5 centromeric side (2DS3S5), KIR2DS3, and KIR2DS4, and KIR2DS5 telomeric side (2DS3S4S5), and KIR3DL1 and KIR3DS1 (3DL1S1). Haplotype cA01~tB04, which contains a 106 kb insertion, was omitted for visualization.