Table 3.
Some databases and tools that summarize the current knowledge on DR.
| Category | Database name | Link | Key features | Reference |
|---|---|---|---|---|
| Drug-target interactions and bioactivity databases | ChEMBL | ebi.ac.uk/chembl/ | Provides bioactivity data, structures and properties, clinical trials and drug annotations references for diseases | (62) |
| PubChem | pubchem.ncbi.nlm.nih.gov/ | Provides chemical structures and physical properties, bioactivity information, current patents, toxicity and safety; among others | (129) | |
| DrugCentral | drugcentral.org/ | Provides chemical structures, chemical entities action, drug mode of action, dosage and pharmacological indications | (130) | |
| DrugTargetCommons (DTC) | drugtargetcommons.fimm.fi/ | Bioactivity data, protein classification, assays and clinical trials data and disease gene associations for many proteins | (131) | |
| DrugBank | drugbank.ca/ | Matches drug bioactivity information with drug-target physiological information | (132) | |
| Epigenetic drugs databases | HEDD | hedds.org/index.jsp | Integration of experimental epigenetic drug datasets, provides information from target-disease, and tools from high-throughput screening | (133) |
| HISTome2 | actrec.gov.in/histome2 | Provides histone proteins data and 127 epidrugs that have been categorized by modifier type; and advanced tools for histone modifier-drug prediction | (134) | |
| dbEM | crdd.osdd.net/raghava/dbem | Provides epigenetic modifiers data in normal and cancer genomes; and information for 54 drug molecules against different epigenetic proteins | (135) | |
| Drug Repurposing databases | PROMISCUOUS | bioinformatics.charite.de/promiscuous | Provides an exhaustive set of drugs (25,000), experimental assays and annotations from protein relationships | (136) |
| REPO Hub | clue.io/repurposing | Repurposing library that assemble a collection of 4,707 compounds, experimentally confirmed, clinical trials and annotations based on literature-reported targets | (137) | |
| RepurposeDB | repurposedb.dudleylab.org | Provides a summarize on drug repositioning studies reported on public databases. Assemble a repertoire of drugs, drug targets and associated disease indications | (138) | |
| repoDB | apps.chiragjpgroup.org/repoDB | Provides information from 1,571 compounds, both approved and failed drugs; as well as computational repositioning tools | (139) | |
| Project Repethio | het.io/repurpose | Provides a compilation of 3394 repurposing candidates based on computational predictions | (140) | |
| Drug Repurposing in cancer databases | ReDO project | redo-project.org/ | Provides a curated list of 270 drugs with pre-clinical and clinical evidence of anti-cancer action | (141) |