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. 2020 Dec 1;4:32. doi: 10.1038/s41698-020-00135-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Histologic phenotypes of primary tumors and paired regional lymph nodes from three patients. Case 1 showed no RVT in the primary tumor, with inflamed immune-activated phenotype in the N1 lymph node, but non-inflamed phenotype in the N2 lymph node. Case 2 showed 5% irRVT in the primary tumor, with inflamed immune-activated phenotype in the N1 lymph node, but non-inflamed phenotype in the N2 lymph node. Case 3 showed 60% irRVT in the primary tumor, with non-inflamed phenotype both in N1 and N2 lymph nodes.