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. 2020 Dec 1;10:20970. doi: 10.1038/s41598-020-77847-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment of successful drug targets within HCGHs and proxy gene sets (left) and the number of additional potential targets identified (right). The different enrichment categories are colour-labelled; for network propagation, the enrichment performance of running HotNet2 is shown together with the enrichment gained from including first neighbours of HCGHs. Odds ratios estimated from the Cochran–Mantel–Haenszel test are given with 95% confidence intervals.