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. 2020 Dec 1;10:20974. doi: 10.1038/s41598-020-77750-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Docked pose of virtual hits in the active site of TNF-α. (a) Compound 1, benzophenone derivative establishes several hydrophobic interactions with crucial residues. (b,c) Compound 2 and 3, thiourea derivatives around the hydrophobic cleft formed by active site residues. (d) Compound 5, flurbiprofen derivative stabilize the TNF-α by making many hydrophobic and three hydrogen bonds with the active site residues. Compounds are shown in different color while protein residues shown in light grey color. Red dash lines represented the hydrogen bond contacts.