Table 1.

Generated hypothesis of pharmacophore models and their shared features with the hit rate of active, inactive and decoy compounds after screening.

S. no	Hypothesis	Shared features	Actives hit rate %	Inactives hit rate %	Decoys hit rate %
1	Hypo_1	Hyd, Hyd, Hyd, HBA	85	33	55
2	Hypo_2	Hyd, Hyd, Hyd, Ar, HBA, HBA	93	33	50
3	Hypo_3	Hyd, Hyd, Hyd, Ar, HBA, HBA	75	50	27
4	Hypo_4	Hyd, Hyd, Ar, HBA, HBA	28	16	22
5	Hypo_5	Hyd, Hyd, Hyd, HBD, HBA, HBA	77	16	27
6	Hypo_6	Hyd, Hyd, Hyd, Ar, HBA, HBA	93	33	50
7	Hypo_7	Hyd, Hyd, Hyd, HBA, HBA	73	16	6
8	Hypo_8	Hyd, Hyd, Hyd, HBA,	85	33	55
9	Hypo_9	Hyd, Hyd, Ar, HBA,	10	0	3
10	Hypo_10	Hyd, Hyd, HBD, HBA	40	33	25
11	Hypo_11	Hyd, Hyd, HBD, HBA	40	33	25
12	Hypo_12	Hyd, Ar, HBA, HBD	3	0	0